Columbia:

• Columbia Museum of Art– one of the best collections of Renaissance art in the US including the only Botticelli fresco outside of Italy

Greenville:

• Greenville County Museum of Art
• Bob Jones Museum and Gallery

Spartanburg:

• Spartanburg Art Museum

Clemson

• Lee Gallery

Charleston:

• Gibbes Museum of Art

Florence:

• Florence County Museum

Myrtle Beach

• Myrtle Beach Art Museum

More info at Discover SC website